Tau isoform mapping across tissues and biofluids reveals a signature distinguishing Alzheimer's disease from amyotrophic lateral sclerosis.

Samir Abu-Rumeileh, Henning Großkopf, Arthur Guthknecht, Alexander Mensch, Dirk Osterloh, Antonia Ratti, Julian Conrad, Caroline Stapf, Julia Krippner, Patrick Oeckl, Gisela Stoltenburg-Didinger, Alessio Maranzano, Petra Steinacker, Christopher M Weise, Lorenzo Barba, Lucio D'Anna, Hans-Wolfgang Klafki, Jens Wiltfang, Vincenzo Silani, Lutz Froelich, Nicola Ticozzi, Lucrezia Hausner, Dietmar Rudolf Thal, Jochen Hans Weishaupt, Ingolf Lachmann, Federico Verde, Markus Otto

DOI: 10.1038/s41467-026-78390-3

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